Carbofuran Toxicity to Vertebrates

Oral LD₅₀: Rats 8–14 mg/kg, Dogs 19 mg/kg.

Carbofuran is also known to be highly toxic to birds. In its granular form, a single grain will kill a bird. Birds often eat numerous grains of the pesticide, mistaking them for seeds, and then die shortly thereafter. Before the granular form was banned by U.S. Environmental Protection Agency‎ in 1991, it was blamed for millions of bird deaths per year. The liquid version of the pesticide is less hazardous to birds since they are not as likely to ingest it directly, but it is still very hazardous. The EPA announced on July 25, 2008 that it intends to ban all forms in the US. The ban requires that no residue be present on domestic or imported foods.

Carbofuran has been illegally used to intentionally poison wildlife in the US, Canada and Great Britain; poisoned wildlife have included coyotes, kites, golden eagles and buzzards. Secondary fatal poisoning of domestic and wild animals has been documented, specifically, raptors (bald eagles and golden eagles), domestic dogs, raccoons, vultures and other scavengers.

In Kenya farmers are using carbofuran to kill lions and other predators.

Toxicity to humans

Carbofuran has one of the highest acute toxicities to humans of any insecticide widely used on field crops (only aldicarb and parathion are more toxic). A quarter teaspoon (1 mL) can be fatal. Most carbofuran is applied by commercial applicators using closed systems with engineered controls so there is no exposure to it in preparation. Since its toxic effects are due to its activity as a cholinesterase inhibitor it is considered a neurotoxic pesticide.